- Avoid browser layout operations http://gent.ilcore.com/2011/03/how-not-to-trigger-layout-in-webkit.html 

- Avoid Jank, use Canary to profile pages (https://www.google.com/intl/en/chrome/browser/canary.html) render recalculations

- Render time must be under 16ms to avoid Jank

- position: fixed is your friend

- upcoming: position: sticky

- Keep event listeners to a minimum

- Reduce the paint cost: keep to a minimum (dev tools -> show paint rectangles)

    - Reduce size of paint areas

    - Reduce the complexity of your paints

          - dev tools -> "Enable constant frame repainting"

          - Note: Styles have a certain cost

Set limits upfront (number of reqs, GCs, paint time, layout, style calculations)

http://jankfree.org

Also watch: Jank Free: Chrome Rendering Performance